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Coli increased antigen binding Pre B cell B cell B cell Unordered antigen genes Ordered antigen genes Somatic mutation Memory cell Plasma cell assembled antibody genes in phage DNA Fab scFv Fv Antibody genes Presentation of the antibody on the B cell or the phage Selection of B cells or phages via antigen binding Affinity maturation Soluble antibody IgD IgM IgD IgM cell IgG Figure 6.
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